Estrin began his career as a writer and producer on Charmed, Dawson's Creek, and Tru Calling, before serving as a co-executive producer of Prison Break.[1][2] He was set to write the script of an ultimately unproduced spin-off, Prison Break: Cherry Hill, along with Prison Break's executive producer Matt Olmstead, both of whom conceived the idea for the spin-off with fellow executive producer, Dawn Parouse.[3] He was also a producer on the film Stranger than Fiction.[1]
In 2018, he served as showrunner on the Netflix show Lost in Space.[4]
Estrin attended the University of Southern California.[2] He and his wife, Kari, had two daughters.[1]
On September 23, 2022, Estrin died while jogging in Hermosa Beach, California, after apparently going into cardiac arrest. He was 51, and was not known to be ill.[6]
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